Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14183559 | 1.00 | CA2 (0.47) | CA2HTR2BMAOAGRM2MAPK1 | |
| SCHEMBL11163644 | 0.80 | CYP2D6 (0.47) | CA2HTR2BMAOAGRM2MAPK1 | |
| SCHEMBL14168364 | 0.80 | MAOA (0.38) | MAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL10151437 | 0.80 | MAOA (0.38) | MAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL10368363 | 0.77 | HTR2B (0.41) | CA2HTR2BMAOA | |
| SCHEMBL10368359 | 0.77 | HTR2B (0.41) | CA2HTR2BMAOA | |
| SCHEMBL9230342 | 0.76 | HTR2B (0.41) | HTR2BMAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL10504741 | 0.76 | CA2 (0.42) | CA2HTR2BMAOAGRM2MAPT | |
| SCHEMBL9230346 | 0.76 | HTR2B (0.41) | HTR2BMAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL9489050 | 0.76 | CA2 (0.42) | CA2HTR2BMAOAGRM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129478-B1 | 2-SULFAMOYLBENZO (B) THIOPHENE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0152340-B1 | 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4788192-A | TOPICALLY APPLYING; FOR GLAUCOMA | MERCK & CO., INC. (US) | 1988-11-29 | — | — | US | disclosed |
| US-4668697-A | Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | disclosed |
| US-4602093-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-07-22 | — | — | US | disclosed |
| US-4544667-A | CARBONIC ANHYDRASE INHIBITOR; VISION DEFECTS | MERCK & CO., INC. (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0152340-A1 | 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| EP-0129478-A2 | 2-Sulfamoylbenzo (b) thiophene derivatives, their preparation and pharmaceutical composition for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | disclosed |