Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16421959 | 0.79 | KDM4E (0.73) | KDM4EHSD17B10TSHRCYP1A2MAPT | |
| SCHEMBL29778192 | 0.79 | CYP1A2 (0.45) | KDM4EHSD17B10TSHRCYP1A2MAPT | |
| SCHEMBL28778207 | 0.79 | CYP1A2 (0.45) | KDM4EHSD17B10TSHRCYP1A2MAPT | |
| SCHEMBL16806057 | 0.76 | CYP1A2 (0.60) | KDM4ETSHRCYP1A2MAPTDCTPP1 | |
| SCHEMBL10373913 | 0.71 | CYP1A2 (0.64) | KDM4EHSD17B10TSHRCYP1A2MAPT | |
| SCHEMBL13373744 | 0.70 | KDM4E (0.43) | KDM4EHSD17B10MAPTALDH1A1HPGD | |
| SCHEMBL13318998 | 0.70 | ALDH1A1 (0.52) | KDM4EHSD17B10TSHRALDH1A1HPGD | |
| SCHEMBL16806042 | 0.69 | MAPT (0.62) | KDM4ETSHRCYP1A2MAPTDCTPP1 | |
| SCHEMBL13566437 | 0.69 | FAAH (0.53) | TSHRCYP1A2MAPTDCTPP1KMT2A | |
| SCHEMBL13373746 | 0.69 | KDM4E (0.47) | KDM4ECYP1A2MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266989-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1990-07-04 | — | — | EP | disclosed |
| US-4801598-A | Dihydropyridine anti-allergic and anti-inflammatory agents | PFIZER INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0266989-A2 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-05-11 | — | — | EP | disclosed |