Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16157003 | 1.00 | PDE3B (0.62) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL16157010 | 0.96 | PDE3B (0.61) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL17446935 | 0.88 | PDE3B (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11036216 | 0.82 | PDE3B (0.46) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL16157004 | 0.82 | PDE3B (0.65) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10888967 | 0.81 | AKR1C3 (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10371084 | 0.81 | PDE3B (0.64) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10353457 | 0.81 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16156987 | 0.81 | PDE3B (0.79) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10554379 | 0.80 | PDE3B (0.62) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175363-B1 | 4,5-DIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1990-01-17 | — | — | EP | disclosed |
| US-4816454-A | CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-03-28 | — | — | US | disclosed |
| EP-0175363-A2 | 4,5-Dihydro-3(2H)-pyridazinones, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |