Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.46 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368593 | 0.82 | PDE3B (0.62) | PDE3BPDE3APDE2AALDH1A1PDE1A | |
| SCHEMBL16157003 | 0.82 | PDE3B (0.62) | PDE3BPDE3APDE2AALDH1A1PDE1A | |
| SCHEMBL16157010 | 0.79 | PDE3B (0.61) | PDE3BPDE3APDE2AALDH1A1PDE1A | |
| SCHEMBL10704539 | 0.79 | PDE3B (0.68) | PDE3BPDE3APDE2AALDH1A1GPR119 | |
| SCHEMBL11013347 | 0.76 | PDE3B (0.45) | PDE3BPDE3APDE2AGPR119SMN1; SMN2 | |
| SCHEMBL10956557 | 0.76 | PDE3B (0.48) | PDE3BPDE3APDE2AGPR119PDE4A | |
| SCHEMBL10888967 | 0.73 | AKR1C3 (0.44) | PDE3BPDE3AALDH1A1GRK6HPGD | |
| SCHEMBL17446935 | 0.73 | PDE3B (0.48) | PDE3BPDE3APDE2AALDH1A1PDE1A | |
| SCHEMBL10961794 | 0.73 | GPR119 (0.54) | PDE3BPDE3APDE2AALDH1A1GPR119 | |
| SCHEMBL11097309 | 0.73 | GPR119 (0.46) | PDE3BPDE3APDE2AALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129791-A2 | Tetrahydropyridazinone derivatives, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1985-01-02 | — | — | EP | disclosed |