Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370543 | 0.86 | CA2 (0.75) | CA2ALDH1A1LMNASRD5A2 | |
| SCHEMBL10368393 | 0.84 | CA2 (1.00) | CA2ALDH1A1LMNA | |
| SCHEMBL10368319 | 0.84 | CA2 (0.52) | CA2CNR1CNR2 | |
| SCHEMBL10371983 | 0.81 | CA2 (0.51) | CA2 | |
| SCHEMBL16237378 | 0.74 | CA2 (0.46) | CA2 | |
| SCHEMBL3009415 | 0.74 | DAO (0.53) | CA2 | |
| SCHEMBL28297051 | 0.73 | CA2 (0.49) | CA2 | |
| SCHEMBL17911192 | 0.72 | CA2 (0.45) | CA2ALDH1A1LMNA | |
| SCHEMBL12224038 | 0.72 | CA2 (0.56) | CA2ALDH1A1LMNASRD5A2CNR1 | |
| SCHEMBL22867155 | 0.72 | CA2 (0.45) | CA2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268396-B1 | 4-(BENZOYL)THIOPHENE(OR FURAN)-SULFONAMIDE AND DERIVATIVES THEREOF FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURES | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |
| EP-0268396-A1 | 4-(benzoyl)thiophene(or furan)-sulfonamide and derivatives thereof for the topical treatment of elevated intraocular pressures | MERCK & CO. INC. (US) | 1988-05-25 | — | — | EP | disclosed |