Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 19/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369923 | 0.86 | CA2 (0.69) | CA2 | |
| SCHEMBL10369811 | 0.85 | CA2 (0.51) | CA2 | |
| SCHEMBL10370700 | 0.81 | CA2 (0.73) | CA2 | |
| SCHEMBL16237378 | 0.74 | CA2 (0.46) | CA2 | |
| SCHEMBL9541276 | 0.74 | CES2 (0.61) | CES2CES1 | |
| SCHEMBL187134 | 0.74 | CES2 (0.61) | CES2CES1 | |
| SCHEMBL10565390 | 0.74 | CA2 (0.47) | CA2 | |
| SCHEMBL10368319 | 0.71 | CA2 (0.52) | CA2 | |
| SCHEMBL10369965 | 0.71 | CA2 (0.66) | CA2 | |
| SCHEMBL3009415 | 0.71 | DAO (0.53) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268396-B1 | 4-(BENZOYL)THIOPHENE(OR FURAN)-SULFONAMIDE AND DERIVATIVES THEREOF FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURES | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |
| EP-0268396-A1 | 4-(benzoyl)thiophene(or furan)-sulfonamide and derivatives thereof for the topical treatment of elevated intraocular pressures | MERCK & CO. INC. (US) | 1988-05-25 | — | — | EP | disclosed |