Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171003 | 0.80 | TP53 (0.40) | IDO1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL6195202 | 0.79 | KMT2A (0.34) | IDO1TDO2PRMT5LMNAKMT2A | |
| SCHEMBL6452038 | 0.77 | ALDH1A1 (0.39) | LMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL2889829 | 0.73 | PDK2 (0.36) | PRMT5LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL23489760 | 0.73 | PDK2 (0.36) | PRMT5LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL8036927 | 0.72 | GABRA1 (0.42) | IDO1TDO2LMNAKMT2AKDM4E | |
| SCHEMBL23579155 | 0.72 | KDM4E (0.44) | LMNAKMT2AKDM4EHTTDHODH | |
| SCHEMBL18892819 | 0.72 | PDK2 (0.36) | IDO1PRMT5LMNAKMT2AKDM4E | |
| SCHEMBL717837 | 0.72 | RAB9A (0.39) | IDO1TDO2KMT2AKDM4EMEN1 | |
| SCHEMBL4609571 | 0.71 | BACE1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217092-B1 | 3-DIMETHYL-MEVALONIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS BASED ON THESE COMPOUNDS, THEIR USE AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-28 | — | — | EP | disclosed |