Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tampramine SCHEMBL120540 | 0.92 | HRH1 (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| Tampramine SCHEMBL30801387 | 0.92 | HRH1 (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10371054 | 0.91 | HRH1 (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10372370 | 0.90 | HRH1 (0.37) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10373430 | 0.90 | HTR1A (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10371655 | 0.90 | CYP2D6 (0.42) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL10371429 | 0.89 | LMNA (0.38) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10370360 | 0.89 | HRH1 (0.36) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| Water SCHEMBL10373998 | 0.89 | HRH1 (0.36) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10635380 | 0.89 | HDAC3 (0.37) | HRH1HTR1ADRD2HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0076017-B1 | PHENYL SUBSTITUTED PYRIDO(1,4)BENZODIAZEPINES AND INTERMEDIATES THEREFOR | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-16 | — | — | EP | disclosed |
| US-4668675-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-05-26 | — | — | US | disclosed |
| US-4556667-A | (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-03 | — | — | US | disclosed |
| US-4447361-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0076017-A2 | Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor | A.H. ROBINS COMPANY, INCORPORATED (US) | 1983-04-06 | — | — | EP | disclosed |