Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.40 |
| ▸ | PRNP | P04156 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tampramine SCHEMBL120540 | 1.00 | HRH1 (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10635380 | 0.97 | HDAC3 (0.37) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10371655 | 0.94 | CYP2D6 (0.42) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10372318 | 0.93 | CCKBR (0.42) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10371054 | 0.93 | HRH1 (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| Tampramine SCHEMBL120541 | 0.92 | HDAC3 (0.39) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| Tampramine SCHEMBL636616 | 0.92 | HDAC3 (0.39) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10370942 | 0.92 | CYP2D6 (0.43) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10373430 | 0.92 | HTR1A (0.40) | HRH1HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL10373753 | 0.92 | HRH1 (0.37) | HRH1HTR1ADRD2HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597126-A | Pharmaceutical composition for preventing or treating cancer comprising CDK4/6 inhibitor and tricyclic antidepressant | 国立癌症中心 | 2024-02-23 | — | — | CN | claimed |
| CN-117597126-A | Pharmaceutical composition for preventing or treating cancer comprising CDK4/6 inhibitor and tricyclic antidepressant | 国立癌症中心 | 2024-02-23 | — | — | CN | disclosed |