Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.47 |
| ▸ | LOX | P28300 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375014 | 0.84 | LOXL2 (0.62) | LOXL2LOXCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL15015273 | 0.82 | LOXL2 (0.43) | LOXL2LOXCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL9839837 | 0.81 | LOXL2 (0.40) | LOXL2LOXCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL10674128 | 0.77 | LOXL2 (0.46) | LOXL2LOXCHRNB2CHRNA4HRH3 | |
| SCHEMBL12949354 | 0.73 | LOX (0.68) | LOXL2LOXHRH3 | |
| SCHEMBL8920977 | 0.73 | LOXL2 (0.43) | LOXL2LOXCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL8920968 | 0.73 | LOXL2 (0.43) | LOXL2LOXCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL14613356 | 0.73 | UHRF1 (0.46) | CHRNB2CHRNA4ALDH1A1TSHRLMNA | |
| SCHEMBL23365986 | 0.72 | TYMS (0.45) | CHRNB2CHRNA4ALDH1A1TSHRLMNA | |
| SCHEMBL3189367 | 0.72 | NOS1 (0.62) | CHRNB2CHRNA4ALDH1A1TSHRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | claimed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | claimed |
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | disclosed |
| US-4567176-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-01-28 | — | — | US | disclosed |
| US-4540699-A | N-Substituted pyridinones having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-09-10 | — | — | US | disclosed |
| EP-0132914-A2 | Imidazolinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-13 | — | — | EP | disclosed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | disclosed |