Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17113293 | 0.84 | NR4A2 (0.70) | NR4A2BRPF1DYRK1ACREBBPALDH1A1 | |
| SCHEMBL5417964 | 0.83 | CLEC4M (0.46) | NR4A2BRPF1CLEC4MALDH1A1LMNA | |
| SCHEMBL7004599 | 0.82 | ALDH1A1 (0.62) | NR4A2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL3762044 | 0.78 | KDM4E (0.50) | NR4A2BRPF1DYRK1AALDH1A1LMNA | |
| SCHEMBL29549088 | 0.77 | PRNP (0.49) | HTTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1936278 | 0.77 | PRNP (0.49) | HTTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL5592328 | 0.77 | NR4A2 (0.49) | NR4A2CREBBPHTTMEN1NPC1 | |
| SCHEMBL30218679 | 0.77 | MEN1 (0.40) | NR4A2DYRK1AHTTMEN1NPC1 | |
| SCHEMBL6684094 | 0.76 | NR4A2 (0.69) | NR4A2CREBBPALDH1A1LMNAHTT | |
| SCHEMBL6029970 | 0.75 | NR4A2 (0.51) | NR4A2BRPF1DYRK1ACLEC4MCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276731-A1 | 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 | Boehringer Ingelheim International GmbH (DE) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009126675-A1 | 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |