Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375596 | 0.80 | HRH3 (0.43) | SIGMAR1ALDH1A1HTR2C | |
| SCHEMBL30061432 | 0.77 | CHRNA7 (0.47) | SIGMAR1CHRNA7ALDH1A1LMNAMEN1 | |
| SCHEMBL10375779 | 0.77 | HRH3 (0.43) | CHRNA7ALDH1A1TRPV6 | |
| SCHEMBL10376883 | 0.77 | HRH3 (0.43) | ALDH1A1LMNA | |
| SCHEMBL10375490 | 0.77 | HRH3 (0.43) | SIGMAR1ABCB1 | |
| SCHEMBL10761904 | 0.77 | HRH3 (0.43) | ALDH1A1LMNA | |
| SCHEMBL10921603 | 0.77 | ABCB1 (0.45) | ABCB1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL9688437 | 0.77 | HRH3 (0.43) | — | |
| SCHEMBL4253607 | 0.77 | ABCB1 (0.72) | SIGMAR1ABCB1MEN1KMT2ADRD2 | |
| SCHEMBL4253600 | 0.77 | ABCB1 (0.72) | SIGMAR1ABCB1MEN1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | claimed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | claimed |
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | disclosed |
| CN-86100131-A | The preparation and the application thereof of octahydro indolizine compound | — | 1986-10-15 | — | — | CN | disclosed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4582836-A | Octahydroindolizine compounds useful as analgesics | MCNEILAB, INC. (US) | 1986-04-15 | — | — | US | disclosed |