Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375839 | 0.94 | — | — | |
| SCHEMBL10375697 | 0.82 | SIGMAR1 (0.64) | SIGMAR1ACHE | |
| SCHEMBL10375715 | 0.81 | SIGMAR1 (0.60) | SIGMAR1ACHE | |
| SCHEMBL10375901 | 0.80 | SIGMAR1 (0.73) | SIGMAR1ACHEGRIN1GRIN2AGRIN2D | |
| SCHEMBL801651 | 0.78 | SIGMAR1 (0.67) | SIGMAR1 | |
| SCHEMBL10375708 | 0.77 | — | — | |
| SCHEMBL30704375 | 0.77 | ACHE (0.60) | ACHEGRIN1GRIN2AGRIN2DGRIN3B | |
| SCHEMBL11183259 | 0.76 | ACHE (0.76) | ACHE | |
| SCHEMBL3254208 | 0.76 | SIGMAR1 (0.67) | SIGMAR1ACHEGRIN1GRIN2AGRIN2D | |
| SCHEMBL3716545 | 0.74 | BAZ2B (0.62) | ACHEGRIN1GRIN2AGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | claimed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | claimed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | claimed |
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | disclosed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |