Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666378 | 0.92 | SIGMAR1 (0.53) | SIGMAR1 | |
| SCHEMBL10375839 | 0.88 | — | — | |
| SCHEMBL10375715 | 0.87 | SIGMAR1 (0.60) | SIGMAR1ACHE | |
| SCHEMBL10377066 | 0.83 | ACHE (0.59) | SIGMAR1ACHE | |
| Carvotroline SCHEMBL29710918 | 0.82 | SIGMAR1 (0.88) | SIGMAR1ACHE | |
| Carvotroline SCHEMBL350602 | 0.82 | SIGMAR1 (0.88) | SIGMAR1ACHE | |
| SCHEMBL10375709 | 0.82 | SIGMAR1 (0.54) | SIGMAR1ACHE | |
| Carvotroline SCHEMBL123737 | 0.81 | SIGMAR1 (0.86) | SIGMAR1ACHE | |
| SCHEMBL30945663 | 0.79 | SIGMAR1 (0.58) | SIGMAR1ACHE | |
| SCHEMBL30704348 | 0.79 | ACHE (0.67) | SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | claimed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | claimed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | claimed |
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | disclosed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |