Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373213 | 0.90 | PDE2A (0.37) | AMY1APDE2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10374338 | 0.89 | PDE3A (0.45) | AMY1APDE2ARUNX1KDM4ECYP1A2 | |
| SCHEMBL10373365 | 0.88 | PDE2A (0.45) | AMY1APDE2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10373843 | 0.82 | CDK4 (0.39) | AMY1APDE3BPDE3APDE5APDE4A | |
| SCHEMBL10374613 | 0.81 | AMY1A (0.36) | AMY1APDE2AKDM4EPDE3BPDE3A | |
| SCHEMBL10372880 | 0.81 | CYP17A1 (0.42) | KDM4ECYP1A2CYP3A4PDE5APDE4D | |
| SCHEMBL10374204 | 0.81 | AMY1A (0.36) | AMY1APDE2ARUNX1KDM4ECYP1A2 | |
| SCHEMBL10374322 | 0.80 | PDE3B (0.45) | AMY1APDE2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10477734 | 0.79 | PGR (0.38) | AMY1APDE3BPDE3APDE5APDE4A | |
| SCHEMBL10375221 | 0.79 | RUNX1 (0.37) | AMY1APDE2ARUNX1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186010-B1 | PYRROLO BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1990-01-31 | — | — | EP | disclosed |
| US-4810801-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1989-03-07 | — | — | US | disclosed |
| US-4710510-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-12-01 | — | — | US | disclosed |
| EP-0186010-A1 | Pyrrolo benzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |