Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 6/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378505 | 1.00 | LMNA (0.46) | LMNARAB9ARECQLMAPTALDH1A1 | |
| SCHEMBL10377561 | 0.88 | ALDH1A1 (0.40) | LMNARAB9AMAPTALDH1A1AKR1C3 | |
| SCHEMBL10377563 | 0.88 | ALDH1A1 (0.40) | LMNARAB9AMAPTALDH1A1AKR1C3 | |
| SCHEMBL10377357 | 0.87 | CYP1A2 (0.46) | KMT2ANPC1MEN1 | |
| SCHEMBL10377359 | 0.87 | CYP1A2 (0.46) | KMT2ANPC1MEN1 | |
| SCHEMBL10377660 | 0.87 | MAPT (0.46) | LMNARAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL10377661 | 0.87 | MAPT (0.46) | LMNARAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL10377662 | 0.86 | RECQL (0.43) | LMNARAB9ARECQLMAPTALDH1A1 | |
| SCHEMBL10377663 | 0.86 | RECQL (0.43) | LMNARAB9ARECQLMAPTALDH1A1 | |
| SCHEMBL10378898 | 0.85 | MAPT (0.48) | LMNARAB9AMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | claimed |
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |