Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377444 | 0.84 | KDM4E (0.56) | NPC1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL10377556 | 0.83 | ALDH1A1 (0.52) | NPC1MAPTRAB9ALMNAHPGD | |
| SCHEMBL10378565 | 0.82 | MAPT (0.47) | NPC1MAPTRAB9AKMT2AHTT | |
| SCHEMBL10378678 | 0.81 | GRM5 (0.43) | NPC1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL10377589 | 0.81 | MAPT (0.46) | NPC1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL10378571 | 0.81 | NR4A1 (0.45) | NPC1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL10683064 | 0.81 | NPC1 (0.50) | NPC1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL10378560 | 0.80 | MAPT (0.47) | MAPTKMT2ANPSR1HTTMAPK1 | |
| SCHEMBL10377414 | 0.78 | PLK1 (0.45) | MAPTRAB9AKMT2AHTTLMNA | |
| SCHEMBL10377855 | 0.77 | CA1 (0.42) | MAPTALDH1A1CA1CA2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | claimed |
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0168037-A2 | 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics | STERLING DRUG INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |