Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377556 | 0.86 | ALDH1A1 (0.52) | NR4A1MAPTSRD5A2HPGDRAB9A | |
| SCHEMBL10378565 | 0.85 | MAPT (0.47) | KMT2AMAPTSRD5A2MAPK1HPGD | |
| SCHEMBL10378678 | 0.83 | GRM5 (0.43) | KMT2AMAPTRAB9ACES2CES1 | |
| SCHEMBL10377589 | 0.83 | MAPT (0.46) | KMT2ANPSR1MAPTMAPK1HPGD | |
| SCHEMBL10378560 | 0.83 | MAPT (0.47) | KMT2ANPSR1MAPTMAPK1HPGD | |
| SCHEMBL10377417 | 0.81 | NPC1 (0.54) | KMT2ANPSR1MAPTMAPK1HPGD | |
| SCHEMBL10377414 | 0.81 | PLK1 (0.45) | KMT2AMAPTSRD5A2HPGDRAB9A | |
| SCHEMBL10377855 | 0.80 | CA1 (0.42) | MAPTPKM | |
| SCHEMBL10378895 | 0.78 | MAPT (0.50) | KMT2ANPSR1MAPTSRD5A2MAPK1 | |
| SCHEMBL10377444 | 0.77 | KDM4E (0.56) | KMT2ANPSR1MAPTMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | claimed |
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0168037-A2 | 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics | STERLING DRUG INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |