Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378565 | 0.88 | MAPT (0.47) | ALDH1A1LMNASRD5A2MAPTGAA | |
| SCHEMBL10378678 | 0.86 | GRM5 (0.43) | ALDH1A1LMNAMAPTCES2CES1 | |
| SCHEMBL10377589 | 0.86 | MAPT (0.46) | LMNAAKR1C3MAPTCES2CES1 | |
| SCHEMBL10378571 | 0.86 | NR4A1 (0.45) | SRD5A2MAPTGAACES2CES1 | |
| SCHEMBL10378560 | 0.86 | MAPT (0.47) | ALDH1A1LMNAAKR1C3MAPTGAA | |
| SCHEMBL10377417 | 0.83 | NPC1 (0.54) | ALDH1A1LMNAMAPTGAACES2 | |
| SCHEMBL10377414 | 0.83 | PLK1 (0.45) | ALDH1A1LMNASRD5A2MAPTL3MBTL1 | |
| SCHEMBL10377855 | 0.82 | CA1 (0.42) | ALDH1A1MAPT | |
| SCHEMBL10378895 | 0.81 | MAPT (0.50) | ALDH1A1LMNASRD5A2MAPTGAA | |
| SCHEMBL10676916 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LMNAAKR1C3SRD5A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0168037-A2 | 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics | STERLING DRUG INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |