Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 7/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379031 | 0.92 | PDE4A (0.33) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10377402 | 0.87 | HPGD (0.33) | PDE4BPDE4DALDH1A1TSHR | |
| SCHEMBL10377468 | 0.87 | DGAT1 (0.34) | PDE4BALDH1A1TSHRCYP2C19 | |
| SCHEMBL10378431 | 0.87 | ALDH1A1 (0.37) | PDE4BPDE4DALDH1A1TSHRCYP2C19 | |
| SCHEMBL10378745 | 0.84 | CYP1A2 (0.37) | PDE4BALDH1A1TSHRCYP2C19 | |
| SCHEMBL10377154 | 0.84 | EPHB4 (0.41) | PDE4BPDE4D | |
| SCHEMBL9352322 | 0.83 | FEN1 (0.47) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10739639 | 0.83 | PDE4B (0.39) | PDE4BPDE4DALDH1A1TSHR | |
| SCHEMBL10657045 | 0.83 | CYP1A2 (0.35) | ALDH1A1TSHRCYP2C19 | |
| SCHEMBL10657628 | 0.82 | CYP1A2 (0.35) | ALDH1A1TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |