Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 3/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MAT2A | P31153 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658078 | 0.88 | SMN1; SMN2 (0.34) | ALDH1A1HSD17B10SMN1; SMN2HKDC1TSHR | |
| SCHEMBL10657045 | 0.85 | CYP1A2 (0.35) | CYP1A2ALDH1A1HSD17B10CYP3A4CYP2C9 | |
| SCHEMBL10379028 | 0.82 | FEN1 (0.34) | ALDH1A1CYP2C19TSHR | |
| SCHEMBL10654050 | 0.81 | KDM4E (0.36) | CYP1A2ALDH1A1HSD17B10CYP2C9LMNA | |
| SCHEMBL10656710 | 0.78 | ALDH1A1 (0.36) | CYP1A2ALDH1A1HSD17B10CYP3A4CYP2C9 | |
| SCHEMBL10655632 | 0.76 | PI4KA (0.36) | CYP1A2ALDH1A1HSD17B10CYP2C9LMNA | |
| SCHEMBL10377468 | 0.75 | DGAT1 (0.34) | CYP1A2ALDH1A1CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL10379031 | 0.75 | PDE4A (0.33) | ALDH1A1SMN1; SMN2CYP2C19TSHRMEN1 | |
| SCHEMBL10653856 | 0.74 | TSHR (0.34) | CYP1A2ALDH1A1HSD17B10CYP3A4CYP2C9 | |
| SCHEMBL9352322 | 0.73 | FEN1 (0.47) | ALDH1A1CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |