Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 2/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL610295 | 0.98 | DNMT1 (0.42) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL2160619 | 0.96 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL11416072 | 0.95 | DNMT1 (0.40) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL600168 | 0.91 | DNMT1 (0.40) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL6830995 | 0.89 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL3700755 | 0.89 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL1961248 | 0.89 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL33439 | 0.89 | HTT (0.42) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL5800741 | 0.89 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL11428634 | 0.89 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113877641-A | Method and apparatus for controlling the movement of biological macromolecules in a solution | 安行生物技术有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-111394444-A | Device preparation using condensed nucleic acid particles | 生命技术公司 | 2020-07-10 | — | — | CN | disclosed |
| WO-1990007730-A1 | PHOTORESIST COMPOSITIONS CONTAINING COBALT (III) COMPOUND AND REDOX TRANSFER LIGAND | EASTMAN KODAK COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |