Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 2/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL2160619 | 0.98 | DNMT1 (0.41) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL10379983 | 0.98 | DNMT1 (0.41) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL11416072 | 0.96 | DNMT1 (0.40) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL600168 | 0.93 | DNMT1 (0.40) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL6830995 | 0.91 | DNMT1 (0.39) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL3700755 | 0.91 | DNMT1 (0.39) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL1961248 | 0.91 | DNMT1 (0.39) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL33439 | 0.91 | HTT (0.42) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL11428634 | 0.91 | DNMT1 (0.41) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL5800741 | 0.91 | DNMT1 (0.41) | DNMT1MAPTHTTTP53STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 332 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250154662-A1 | THERMAL ATOMIC LAYER ETCHING PROCESSES | ASM IP HOLDING B.V. (NL) | 2025-05-15 | — | — | US | claimed |
| US-12252590-B2 | Acetoacetylated and (meth)acrylated resin compositions and thermosets and foams therefrom | NDSU RESEARCH FOUNDATION (US) | 2025-03-18 | — | — | US | claimed |
| US-12227738-B2 | Method of single-stranded RNA purification | SARTORIUS BIA SEPARATIONS D.O.O. (SI) | 2025-02-18 | — | — | US | claimed |
| CN-114773307-B | Non-isocyanate polyurethane monomer and thermosetting non-isocyanate shape memory polyurethane, and preparation and recycling methods thereof | 中国科学院兰州化学物理研究所 | 2024-01-26 | — | — | CN | claimed |
| US-20220290005-A1 | COATINGS WITH TUNABLE AMINE DENSITY | Cowper Sciences Inc. | 2022-09-15 | — | — | US | claimed |
| CN-114773307-A | Non-isocyanate-based polyurethane monomer and thermosetting non-isocyanate-based shape memory polyurethane, and preparation and recycling methods thereof | 中国科学院兰州化学物理研究所 | 2022-07-22 | — | — | CN | claimed |
| CN-113527313-B | Preparation method and application of water-soluble supermolecule organic cage-shaped compound for detecting pyridinium substances in water | 浙江浙能技术研究院有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-109906489-B | Flexible electrode and method for producing a flexible electrode | 高丽大学校产学协力团 | 2022-02-25 | — | — | CN | claimed |
| US-11168284-B2 | Laundry builders and surfactants derived from bio-based hydroxyacids and epoxides | BATTELLE MEMORIAL INSTITUTE (US) | 2021-11-09 | — | — | US | claimed |
| CN-113527313-A | Preparation method and application of water-soluble supermolecule organic cage-shaped compound for detecting pyridinium substances in water | 浙江浙能技术研究院有限公司 | 2021-10-22 | — | — | CN | claimed |
| US-20040132993-A1 | Antiviral and antimicrobial guanidine or biguanidine derivatives | SHETTY B VITHAL (US) | 2004-07-08 | — | — | US | claimed |
| US-20020042495-A1 | Polyamide ligand-containing polymeric resins and methods of using the same for removing, separating and/or concentrating desired metal ions from solutions | BRUENING RONALD L (US) | 2002-04-11 | — | — | US | claimed |
| JP-2001507724-A | — | — | 2001-06-12 | — | — | JP | claimed |
| EP-0411774-B2 | Improvements to multifilament apparel yarns of nylon | DU PONT (US) | 2000-06-21 | — | — | EP | claimed |
| EP-0979266-A2 | NOVEL WATER SOLUBLE METAL WORKING FLUIDS | Solutia Inc. (US) | 2000-02-16 | — | — | EP | claimed |
| WO-1998008919-A2 | NOVEL WATER SOLUBLE METAL WORKING FLUIDS | SOLUTIA INC. (US) | 1998-03-05 | — | — | WO | claimed |
| US-5202182-A | Used in hosiery | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-04-13 | — | — | US | claimed |
| US-5137666-A | Nylon 66 modified with nylon 6 monomer or 2-methyl-pentamethylenediamine; hosiery | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-11 | — | — | US | claimed |
| EP-0411774-A1 | Improvements to multifilament apparel yarns of nylon | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-02-06 | — | — | EP | claimed |
| US-4847315-A | SOLUTION POLYMERIZATION OF TRIS/2-AMINOETHYL/AMINE, DECYANDIAMIDE, FORMALDEHYDE AND DICARBOXYLIC ACID AND/OR EPTICHLOROHYDRIN; ALKYL KETENE DIMER EMULSIONS | W. R. GRACE AB (SE) | 1989-07-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132993-A1 | Antiviral and antimicrobial guanidine or biguanidine derivatives | GMPS, GDA, GANC | DNMT1 746/4885MAPT 3246/4885HTT 2457/4885 |
| US-20220290005-A1 | COATINGS WITH TUNABLE AMINE DENSITY | CHRM1, C5, CHRM2 | DNMT1 71/4885MAPT 1384/4885HTT 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.