Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.51 |
| ▸ | SCN2B | O60939 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.51 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324714 | 0.87 | NR3C1 (0.39) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10380273 | 0.86 | SCN9A (0.39) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10379911 | 0.83 | SCN9A (0.58) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10379940 | 0.82 | SCN9A (0.67) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10325622 | 0.79 | CYP11B2 (0.36) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL15397464 | 0.73 | SCN9A (0.73) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10324443 | 0.71 | SCN9A (0.70) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10379434 | 0.71 | SCN9A (0.41) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL10380868 | 0.70 | SCN9A (0.43) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL368672 | 0.69 | SCN9A (0.65) | SCN9ASCN5ASCN2BSCN1ASCN1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |