Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 11/20 | 0.69 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.65 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.60 |
| ▸ | CBFB | Q13951 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10326325 | 0.89 | NPBWR1 (0.55) | NPBWR1DGAT1KCNH2SOAT1 | |
| SCHEMBL900794 | 0.85 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL30726458 | 0.83 | NPBWR1 (0.63) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL27039849 | 0.83 | NPBWR1 (0.63) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL10325798 | 0.80 | NPBWR1 (0.64) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL19175769 | 0.79 | DGAT1 (0.77) | DGAT1KCNH2SOAT1 | |
| SCHEMBL10326011 | 0.79 | DGAT1 (0.64) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL10381149 | 0.79 | NPBWR1 (1.00) | NPBWR1DGAT1KCNH2SOAT1 | |
| SCHEMBL529750 | 0.79 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL6325971 | 0.79 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013130370-A2 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |