Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.74 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.74 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.67 |
| ▸ | CBFB | Q13951 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10326035 | 0.88 | NPBWR1 (0.58) | NPBWR1DGAT1KCNH2SOAT1TRPV1 | |
| SCHEMBL900794 | 0.85 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL6325971 | 0.85 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1 | |
| SCHEMBL4184260 | 0.85 | DGAT1 (1.00) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL10381149 | 0.85 | NPBWR1 (1.00) | NPBWR1DGAT1KCNH2SOAT1TRPV1 | |
| SCHEMBL20445295 | 0.85 | NPBWR1 (1.00) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL27040116 | 0.85 | NPBWR1 (0.72) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL30726466 | 0.85 | NPBWR1 (0.72) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL19489313 | 0.83 | NPBWR1 (0.75) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL4184180 | 0.80 | DGAT1 (0.78) | NPBWR1DGAT1KCNH2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015693-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-02-02 | — | — | WO | disclosed |
| WO-2012015693-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-02-02 | — | — | WO | disclosed |