Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27630082 | 0.88 | FYN (0.50) | METJAK2MAP4K3ALKROS1 | |
| SCHEMBL3122066 | 0.87 | MET (0.56) | METJAK2MAP4K3MAP4K4ALK | |
| SCHEMBL27630135 | 0.87 | MET (0.64) | METJAK2MAP4K3MAP4K4FYN | |
| SCHEMBL487679 | 0.85 | MET (0.57) | METJAK2MAP4K3MAP4K4ALK | |
| SCHEMBL488147 | 0.84 | MET (0.52) | METJAK2MAP4K3MAP4K4 | |
| SCHEMBL30452799 | 0.84 | MET (0.52) | METJAK2MAP4K3MAP4K4ALK | |
| SCHEMBL488295 | 0.84 | MET (0.52) | METJAK2MAP4K3MAP4K4ALK | |
| SCHEMBL30453038 | 0.84 | MET (0.52) | METJAK2MAP4K3MAP4K4 | |
| SCHEMBL28756897 | 0.83 | MET (0.51) | METJAK2MAP4K3MAP4K4ALK | |
| SCHEMBL27630129 | 0.83 | MET (0.74) | METJAK2MAP4K3MAP4K4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | claimed |
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | disclosed |