Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxirane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dioxane SCHEMBL5177507 | 0.98 | L3MBTL1 (0.49) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| Dioxane SCHEMBL11309706 | 0.98 | L3MBTL1 (0.49) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| SCHEMBL7631490 | 0.94 | ALDH1A1 (0.46) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| SCHEMBL156883 | 0.94 | ALDH1A1 (0.53) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| Fluoride SCHEMBL6570833 | 0.91 | GAA (0.59) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| Tetrahydrofuran SCHEMBL5252352 | 0.90 | ALDH1A1 (0.48) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| Tetrahydrofuran SCHEMBL2775004 | 0.90 | ALDH1A1 (0.48) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| Tetrahydrofuran SCHEMBL7631486 | 0.90 | ALDH1A1 (0.48) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| SCHEMBL28620748 | 0.89 | L3MBTL1 (0.43) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| SCHEMBL31313 | 0.89 | GAA (0.62) | ALDH1A1LMNAL3MBTL1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658745-B | Film printing conductive composition and Thin film conductive pattern forming method | 昭和电工株式会社 | 2019-06-04 | — | — | CN | disclosed |
| WO-1990013590-A1 | HYDROLYZABLE SILICONE POLYMERS | GAF CHEMICALS CORPORATION (US) | 1990-11-15 | — | — | WO | disclosed |