SCHEMBL10385263

SCHEMBL10385263

CCCCCCCCCCCCc1ccc2nn(-c3cc(C(C)(C)c4ccccc4)cc(C(C)(C)c4ccccc4)c3O)nc2c1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KAT8 Q9H7Z6 2/20 0.34
PPARA Q07869 2/20 0.34
S1PR4 O95977 3/20 0.33
S1PR1 P21453 3/20 0.33
S1PR5 Q9H228 3/20 0.33
MAPT P10636 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
PPARG P37231 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8861271 0.87 NPC1 (0.38) PPARAMAPTPPARG
SCHEMBL8861274 0.87 NPC1 (0.38) PPARAMAPTPPARG
SCHEMBL4824480 0.87 NPC1 (0.38) PPARAMAPTPPARG
SCHEMBL13015016 0.86 NPC1 (0.38) MAPTTDP1
SCHEMBL10359244 0.85 NPC1 (0.35) S1PR1
SCHEMBL10384689 0.84 CNR2 (0.39)
SCHEMBL2639249 0.84 ACSS2 (0.35)
SCHEMBL2638154 0.84 TRPV1 (0.38) S1PR4S1PR1S1PR5
SCHEMBL5873319 0.84 TRPV1 (0.38) S1PR4S1PR1S1PR5
SCHEMBL10484223 0.82 CNR2 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4904712-A PHOTOSTABILIZERS/AGENTS/ CIBA-GEIGY CORPORATION (US) 1990-02-27 US claimed
US-4727158-A PHOTOSTABILITY CIBA-GEIGY CORPORATION (US) 1988-02-23 US claimed
US-4904712-A PHOTOSTABILIZERS/AGENTS/ CIBA-GEIGY CORPORATION (US) 1990-02-27 US disclosed
US-4847367-A PHOTOSTABILIZERS, CHEMICAL INTERMEDIATE CIBA-GEIGY CORPORATION (US) 1989-07-11 US disclosed
US-4727158-A PHOTOSTABILITY CIBA-GEIGY CORPORATION (US) 1988-02-23 US disclosed