SCHEMBL2638154

SCHEMBL2638154

CCCCCCCCCc1cc(-n2nc3ccc(C(F)(F)F)cc3n2)c(O)c(C(C)(C)c2ccccc2)c1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.38
PLK1 P53350 2/20 0.36
S1PR4 O95977 3/20 0.33
S1PR1 P21453 3/20 0.33
S1PR5 Q9H228 2/20 0.33
ADORA3 P0DMS8 1/20 0.33
CNR2 P34972 1/20 0.33
UBE2M P61081 1/20 0.32
DCUN1D1 Q96GG9 1/20 0.32
HSD11B1 P28845 1/20 0.32
EIF4A1 P60842 1/20 0.32
PLK3 Q9H4B4 1/20 0.32
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5873319 1.00 TRPV1 (0.38) TRPV1PLK1S1PR4S1PR1S1PR5
SCHEMBL6444240 0.92 NPC1 (0.33) TRPV1ADORA3CNR2LMNASMN1; SMN2
SCHEMBL2637632 0.91 TLR8 (0.34)
SCHEMBL8861274 0.90 NPC1 (0.38) ADORA3CNR2LMNAPTGS2
SCHEMBL4824480 0.90 NPC1 (0.38) ADORA3CNR2LMNAPTGS2
SCHEMBL8861271 0.90 NPC1 (0.38) ADORA3CNR2LMNAPTGS2
SCHEMBL13015016 0.89 NPC1 (0.38) TRPV1CNR2HSD11B1LMNAPTGS2
SCHEMBL2638398 0.89 KDM4E (0.34) LMNASMN1; SMN2
SCHEMBL16182319 0.86 FFAR1 (0.39)
SCHEMBL13546050 0.86 CNR2 (0.35) CNR2UBE2MDCUN1D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391949-B1 None US claimed
JP-4705249-B2 2011-06-22 JP claimed
US-7288583-B2 Method of content protection with durable UV absorbers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-10-30 US claimed
EP-1175467-B1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM CIBA SC HOLDING AG (CH) 2006-06-14 EP claimed
US-20050123691-A1 Photo-cured and stabilized coatings SUHADOLNIK JOSEPH (US) 2005-06-09 US claimed
CN-1186417-C Stabilized adhesive compositions containing highly soluble, red-shifted, photostable benzotriazole UV absorbers and laminates made therefrom CIBA SC HOLDING AG (CH) 2005-01-26 CN claimed
US-20040191447-A1 storage of food, beverages, drugs or cosmetics in radiation transparent plastic containers having coatings comprising stabilizer agents selected from hydroxyphenyl benzotriazole ultraviolet radiation absorber materials ANDREWS STEPHEN M (US) 2004-09-30 US claimed
US-6797751-B2 A CLEAR OR LIGHTLY COLORED PLASTIC CONTAINERS OR FILMS COMPRISING A BENZOTRIAZOLES OR TRIS-ARYL-S-TRIAZINES STABILIZER; PROTECTIVE DEVICES FOR FOODS, BEVERAGES, DRUGS, COSMETICS, SHAMPOO CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-28 US claimed
EP-1448613-A1 CURABLE MIXTURES COMPRISING UV-ABSORBER, ACYLPHOSPHINOXIDE AND HYDROXY KETONE PHOTOINITIATOR Ciba SC Holding AG (CH) 2004-08-25 EP claimed
US-6677392-B2 USED TO STABILIE NATURAL, SEMI-SYNTHETIC OR SYNTHETIC POLYMER. CIBA SPECIALTY CHEMICALS CORPORATION 2004-01-13 US claimed
WO-2002012202-A2 PROCESSES FOR THE PREPARATION OF BENZOTRIAZOLE UV ABSORBERS CIBA SPECIALTY CHEMICALS HOLDINGS INC. (CH) 2002-02-14 WO claimed
EP-1175467-A1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM Ciba SC Holding AG (CH) 2002-01-30 EP claimed
US-20010034449-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-10-25 US claimed
US-20010031872-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-10-18 US claimed
US-6296674-B1 Candle wax stabilized with red-shift benzotriazoles CIBA SPECIALTY CHEMICALS CORPORATION 2001-10-02 US claimed
US-20010018520-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-08-30 US claimed
WO-2001057125-A1 CANDLE WAX STABILIZED WITH RED-SHIFTED BENZOTRIAZOLES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-08-09 WO claimed
US-6268415-B1 POLYMERS AND STABILIZERS FOR ENHANCED STABILITY CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-31 US claimed
US-6187845-B1 LAMINATION OR MULTILAYER STRUCTURE CIBA SPECIALTY CHEMICALS CORPORATION 2001-02-13 US claimed
WO-2000066676-A1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-11-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034449-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 TRPV1 4596/4885PLK1 1295/4885S1PR4 3034/4885
US-20010018520-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 TRPV1 4596/4885PLK1 1295/4885S1PR4 3034/4885
US-20010031872-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 TRPV1 4596/4885PLK1 1295/4885S1PR4 3034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.