Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6356446 | 0.76 | GRIK1 (0.39) | GRIK1KMT2AGRIA1GRIA2GRIA4 | |
| SCHEMBL2673714 | 0.76 | GPR119 (0.38) | KMT2AMAPTALDH1A1 | |
| SCHEMBL9521958 | 0.74 | ADRA1A (0.34) | MAPTTP53 | |
| SCHEMBL20262411 | 0.73 | KMT2A (0.49) | GRIK1KMT2AGRIA1GRIA2GRIA4 | |
| SCHEMBL17266586 | 0.72 | MAPT (0.39) | MAPTTP53 | |
| SCHEMBL20262491 | 0.71 | ADRA1A (0.47) | GRIK1KMT2AGRIA1GRIA2GRIA4 | |
| SCHEMBL9621035 | 0.71 | ADRA1A (0.57) | MAPTTP53 | |
| SCHEMBL10456507 | 0.70 | MAPT (0.38) | MAPTTP53 | |
| SCHEMBL9819387 | 0.70 | GRIK1 (0.42) | GRIK1GRIA1GRIA2GRIA4GRIK3 | |
| SCHEMBL3205780 | 0.69 | MAPT (0.37) | MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4958044-A | 2-aza-4-(alkoxycarbonyl)spiro[4,5]-decan-3-one | LONZA LTD. (CH) | 1990-09-18 | — | — | US | disclosed |
| US-4956473-A | ANTICONVULSANTS | LONZA LTD. (CH) | 1990-09-11 | — | — | US | disclosed |