Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | CCR1 | P32246 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | CCR8 | P51685 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011852 | 0.86 | KMT2A (0.56) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL516559 | 0.86 | CCR1 (0.63) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL28597833 | 0.79 | KDM4E (0.65) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL29984681 | 0.79 | KDM4E (0.65) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL30080768 | 0.79 | KDM4E (1.00) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL23714069 | 0.79 | KMT2A (0.65) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL700910 | 0.79 | KDM4E (1.00) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL196848 | 0.78 | KMT2A (0.68) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL1036682 | 0.78 | KDM4E (0.44) | KDM4EKMT2AMEN1HSP90AA1NPC1 | |
| SCHEMBL1036680 | 0.78 | KDM4E (0.44) | KDM4EKMT2AMEN1HSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871941-B2 | 8-bromo-5-quinolinecarboxaldehyde oxime | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-10-28 | — | — | US | disclosed |
| US-20140249314-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-02-06 | — | — | US | disclosed |
| US-8552218-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20130029845-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-01-31 | — | — | US | disclosed |
| CN-101351456-B | Isoxazolines for controlling invertebrate pests | DU PONT | 2012-10-03 | — | — | CN | disclosed |
| US-8231888-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110263641-A1 | Isoxazolines For Controlling Invertebrate Pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-7964204-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1973888-B1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | CORTEVA AGRISCIENCE LLC | 2010-09-16 | — | — | US | disclosed |
| CN-101351456-A | Isoxazolines for controlling invertebrate pests | DU PONT (US) | 2009-01-21 | — | — | CN | disclosed |
| EP-1973888-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079162-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249314-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | KDM4E 4196/4885KMT2A 3232/4885MEN1 4027/4885 |
| US-20130029845-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | KDM4E 4196/4885KMT2A 3232/4885MEN1 4027/4885 |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | C1S, C3AR1, CBR3 | KDM4E 4124/4885KMT2A 3131/4885MEN1 3828/4885 |
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | KDM4E 4196/4885KMT2A 3232/4885MEN1 4027/4885 |
| US-20110263641-A1 | Isoxazolines For Controlling Invertebrate Pests | C1S, C3AR1, CBR3 | KDM4E 4249/4885KMT2A 3193/4885MEN1 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.