Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10613 | 0.90 | TRPA1 (0.39) | DDB1CRBNTRPA1 | |
| SCHEMBL2790916 | 0.69 | DDB1 (0.49) | DDB1CRBNTRPA1LMNA | |
| SCHEMBL10309 | 0.69 | POLB (0.43) | DDB1CRBNTRPA1POLBKIF11 | |
| SCHEMBL12187 | 0.68 | TRPA1 (0.42) | DDB1CRBNTRPA1 | |
| SCHEMBL15013072 | 0.67 | TRPA1 (0.49) | DDB1CRBNTRPA1GAALMNA | |
| SCHEMBL7734467 | 0.65 | SMN1; SMN2 (0.38) | TRPA1POLBKIF11GAATSHR | |
| SCHEMBL15014118 | 0.64 | DDB1 (0.44) | DDB1CRBNTRPA1KDM4E | |
| SCHEMBL5480634 | 0.64 | DDB1 (0.50) | DDB1CRBNTRPA1 | |
| SCHEMBL10109530 | 0.64 | ALDH1A1 (0.36) | POLBGAATSHRHTTLMNA | |
| SCHEMBL2986 | 0.63 | TRPA1 (0.52) | DDB1CRBNTRPA1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011043954-A1 | NOVEL TRPA1 ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-04-14 | — | — | WO | disclosed |