Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388212 | 0.74 | NPC1 (0.50) | ALDH1A1MEN1KMT2ARECQLRAB9A | |
| SCHEMBL913055 | 0.71 | GRM1 (0.51) | ALDH1A1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL11534203 | 0.71 | MEN1 (0.45) | TDP1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL11840961 | 0.70 | GAA (0.43) | ALDH1A1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL10269831 | 0.68 | GRM1 (0.50) | TDP1ALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL11778276 | 0.67 | USP2 (0.55) | TDP1ALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL11790890 | 0.67 | ALDH1A1 (0.45) | TDP1ALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL11088774 | 0.65 | TDP1 (0.47) | TDP1ALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL21294480 | 0.65 | ACSS2 (0.55) | ALDH1A1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL11791186 | 0.65 | USP2 (0.52) | TDP1ALDH1A1MEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4966906-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4952588-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-08-28 | — | — | US | disclosed |
| EP-0317991-A2 | 1-Aryl-3-quinoline- and 1-aryl-3-isoquinoline-carboxamides, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-05-31 | — | — | EP | disclosed |
| US-4786644-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-11-22 | — | — | US | disclosed |