Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11535382 | 0.76 | POLB (0.44) | MEN1KMT2AHTTKDM4EGAA | |
| SCHEMBL11533430 | 0.76 | HPGD (0.40) | HTTNPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL11533101 | 0.74 | KMT2A (0.40) | MEN1KMT2AHTTKDM4EGAA | |
| SCHEMBL10388451 | 0.71 | TDP1 (0.50) | MEN1KMT2AGAANPC1CYP1A2 | |
| SCHEMBL11664943 | 0.71 | NPC1 (0.31) | HTTNPC1RAB9AALDH1A1 | |
| SCHEMBL913055 | 0.70 | GRM1 (0.51) | MEN1KMT2AKDM4EGAANPC1 | |
| SCHEMBL11840961 | 0.69 | GAA (0.43) | MEN1KMT2AHTTKDM4EGAA | |
| SCHEMBL2654124 | 0.68 | NPC1 (0.77) | MEN1KMT2AHTTKDM4EGAA | |
| SCHEMBL913936 | 0.68 | KCNMA1 (0.48) | MEN1KMT2AHTTKDM4EGAA | |
| SCHEMBL913799 | 0.68 | GAA (0.47) | MEN1KMT2AHTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4098794-A | N-Thiazolyl-5,6-dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides | WARNER-LAMBERT COMPANY (US) | 1978-07-04 | — | — | US | claimed |
| US-4134896-A | 5,6-Dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides, and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4134900-A | 5,6-Dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides, and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4098794-A | N-Thiazolyl-5,6-dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides | WARNER-LAMBERT COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
| US-4098794-A | N-Thiazolyl-5,6-dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides | WARNER-LAMBERT COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
| US-4097441-A | 5,6-Dihydro-4-oxo-4H-thieno 2,3-b!thiopyran-5-carboxamides | WARNER-LAMBERT COMPANY (US) | 1978-06-27 | — | — | US | disclosed |
| US-4092325-A | 5,6-Dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides, and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1978-05-30 | — | — | US | disclosed |