Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GLI1 | P08151 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369352 | 0.72 | LMNA (0.50) | MEN1KMT2ALMNAPOLBHPGD | |
| SCHEMBL3762346 | 0.70 | HRH3 (0.50) | HPGDGAAALDH1A1 | |
| SCHEMBL3757509 | 0.66 | MEN1 (0.54) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL29408555 | 0.65 | AR (0.50) | LMNATDP1TSHRGAAALDH1A1 | |
| SCHEMBL3871304 | 0.65 | AR (0.50) | LMNATDP1TSHRGAAALDH1A1 | |
| SCHEMBL1039609 | 0.65 | HPGD (0.43) | KMT2AHPGDTSHRGAAALDH1A1 | |
| SCHEMBL3766365 | 0.64 | ALDH1A1 (0.45) | MEN1KMT2ALMNAPOLBHPGD | |
| SCHEMBL3757416 | 0.63 | ALDH1A1 (0.44) | MEN1KMT2ALMNAPOLBHPGD | |
| SCHEMBL13905030 | 0.63 | HTT (0.57) | MEN1KMT2AHPGDTSHRALDH1A1 | |
| SCHEMBL11498257 | 0.63 | ALDH1A1 (0.56) | MEN1KMT2ALMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581490-B1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROLE-2-CARBOXAMIDES | GRUENENTHAL GMBH (DE) | 2011-01-26 | — | — | EP | claimed |