Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757509 | 0.82 | MEN1 (0.54) | HRH3ALDH1A1GAAKDM4E | |
| SCHEMBL3757416 | 0.79 | ALDH1A1 (0.44) | HRH3HPGDALDH1A1GAAKDM4E | |
| SCHEMBL4659048 | 0.79 | HRH3 (0.54) | HRH3ALDH1A1KDM4E | |
| SCHEMBL3766365 | 0.77 | ALDH1A1 (0.45) | HRH3HPGDALDH1A1GAAKDM4E | |
| SCHEMBL4657901 | 0.77 | HRH3 (0.50) | HRH3ALDH1A1KDM4E | |
| SCHEMBL31369352 | 0.75 | LMNA (0.50) | HPGDALDH1A1GAAKDM4E | |
| SCHEMBL3761968 | 0.73 | TP53 (0.49) | HPGDALDH1A1GAAKDM4E | |
| N-Benzylmethylamine SCHEMBL5556336 | 0.72 | NCF1 (0.50) | HRH3KDM4E | |
| SCHEMBL13684982 | 0.71 | SRC (0.47) | HRH3HPGDALDH1A1 | |
| SCHEMBL3772602 | 0.71 | NPC1 (0.53) | HRH3HPGDALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751101-B1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | claimed |
| US-7842812-B2 | Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2010-11-30 | — | — | US | claimed |
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | claimed |
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | claimed |
| EP-1751101-B1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | disclosed |
| US-7842812-B2 | Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | AVPR2, GPR119, AVPR1B | HRH3 336/4885HPGD 1449/4885ALDH1A1 1027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.