Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 9/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10587512 | 1.00 | GCGR (0.40) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL10397209 | 0.86 | GCGR (0.44) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL8949683 | 0.83 | GCGR (0.53) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL8846314 | 0.81 | GCGR (0.44) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL10397582 | 0.81 | GCGR (0.40) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL8949786 | 0.80 | GCGR (0.47) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL9744058 | 0.76 | GCGR (0.43) | GCGRMAPK10MAPK14HMGCRESR1 | |
| SCHEMBL9380517 | 0.75 | RXRA (0.47) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL10397220 | 0.74 | HMGCR (0.51) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL10397221 | 0.74 | HMGCR (0.51) | GCGRHMGCRESR1CHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946841-A | INHIBITORS OF HYDROXYMETHYLGLUTARIC ACID-COENZYME A REDUCTASE | HOECHST AKTIENGESELLACHAFT (DE) | 1990-08-07 | — | — | US | disclosed |
| EP-0324347-A2 | 3,5-Dihydroxycarboxylic acids and their derivatives, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-07-19 | — | — | EP | disclosed |