Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 13/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10587512 | 0.86 | GCGR (0.40) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL10397208 | 0.86 | GCGR (0.40) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL8846314 | 0.85 | GCGR (0.44) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL8949603 | 0.81 | GCGR (0.58) | GCGRMAPK10MAPK14 | |
| SCHEMBL10397582 | 0.80 | GCGR (0.40) | GCGRPTGS2MAPK10MAPK14MAPK9 | |
| SCHEMBL8878536 | 0.78 | GCGR (0.46) | GCGRPTGS2ALDH1A1 | |
| SCHEMBL8877859 | 0.77 | GCGR (0.45) | GCGR | |
| SCHEMBL8949673 | 0.77 | GCGR (0.50) | GCGRMAPK10MAPK14ALDH1A1 | |
| SCHEMBL8879706 | 0.76 | GCGR (0.44) | GCGR | |
| SCHEMBL8878486 | 0.76 | GCGR (0.44) | GCGRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946841-A | INHIBITORS OF HYDROXYMETHYLGLUTARIC ACID-COENZYME A REDUCTASE | HOECHST AKTIENGESELLACHAFT (DE) | 1990-08-07 | — | — | US | disclosed |
| EP-0324347-A2 | 3,5-Dihydroxycarboxylic acids and their derivatives, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-07-19 | — | — | EP | disclosed |