Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 14/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399594 | 1.00 | TGM2 (0.62) | TGM2SMN1; SMN2CES1ALDH1A1MAPT | |
| SCHEMBL13244119 | 0.83 | SMN1; SMN2 (0.61) | TGM2SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL2512919 | 0.81 | SMN1; SMN2 (0.59) | TGM2SMN1; SMN2CES1ALDH1A1MAPT | |
| SCHEMBL12200893 | 0.81 | SMN1; SMN2 (0.59) | TGM2SMN1; SMN2CES1ALDH1A1MAPT | |
| SCHEMBL10399806 | 0.76 | TGM2 (0.64) | TGM2SMN1; SMN2CES1ALDH1A1MAPT | |
| SCHEMBL10399808 | 0.76 | TGM2 (0.64) | TGM2SMN1; SMN2CES1ALDH1A1MAPT | |
| SCHEMBL397664 | 0.75 | SMN1; SMN2 (1.00) | TGM2SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL11892099 | 0.75 | SMN1; SMN2 (1.00) | TGM2SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL397665 | 0.75 | SMN1; SMN2 (1.00) | TGM2SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL30716604 | 0.72 | CES1 (1.00) | TGM2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977178-A | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4879391-A | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents | PFIZER INC. (US) | 1989-11-07 | — | — | US | disclosed |
| US-4861880-A | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4476307-A | Heteroylidene indolone compounds | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0104860-A1 | 1-Phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1984-04-04 | — | — | EP | disclosed |