Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12200893 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPTNPSR1PDPK1 | |
| SCHEMBL13244119 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MAPTNPSR1PDPK1 | |
| SCHEMBL10399592 | 0.81 | TGM2 (0.62) | SMN1; SMN2ALDH1A1MAPTNPSR1TGM2 | |
| SCHEMBL10399594 | 0.81 | TGM2 (0.62) | SMN1; SMN2ALDH1A1MAPTNPSR1TGM2 | |
| SCHEMBL7795435 | 0.75 | TDP2 (0.53) | PDPK1KDRTGM2RETFLT3 | |
| SCHEMBL397664 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPTNPSR1KDR | |
| SCHEMBL397665 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPTNPSR1KDR | |
| SCHEMBL11892099 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPTNPSR1KDR | |
| SCHEMBL6967576 | 0.73 | PDPK1 (0.72) | PDPK1KDRRETFLT3PDGFRB | |
| SCHEMBL6967581 | 0.73 | PDPK1 (0.72) | PDPK1KDRRETFLT3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748601-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-06-10 | — | — | US | disclosed |
| US-8034821-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-10-11 | — | — | US | disclosed |
| US-20100256171-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-07 | — | — | US | disclosed |
| US-7687506-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090221614-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (CA) | 2009-09-03 | — | — | US | disclosed |
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-12 | — | — | US | disclosed |
| WO-2005000197-A2 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | DSTYK, TTK, SBK1 | SMN1; SMN2 4647/4885ALDH1A1 3691/4885MAPT 3086/4885 |
| US-20090221614-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | DSTYK, TTK, SBK1 | SMN1; SMN2 4647/4885ALDH1A1 3691/4885MAPT 3086/4885 |
| US-20100256171-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | DSTYK, TTK, SBK1 | SMN1; SMN2 4647/4885ALDH1A1 3691/4885MAPT 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.