SCHEMBL30716604

SCHEMBL30716604

O=C1Nc2cccc(Cl)c2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 1.00
TGM2 P21980 9/20 0.54
NSD2 O96028 1/20 0.50
BCHE P06276 1/20 0.50
DAO P14920 1/20 0.50
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
PBRM1 Q86U86 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL282066 1.00 CES1 (1.00) CES1TGM2NSD2BCHEDAO
Nitrogen SCHEMBL29242307 0.96 CES1 (0.92) CES1TGM2NSD2BCHEDAO
SCHEMBL5740595 0.76 CES1 (0.61) CES1TGM2PBRM1
SCHEMBL9835981 0.76 CES1 (0.61) CES1TGM2PBRM1
SCHEMBL11543833 0.76 CES1 (0.61) CES1TGM2PBRM1
SCHEMBL2136384 0.75 CES1 (0.60) CES1DAOMAOAMAOBPBRM1
SCHEMBL4242823 0.75 CES1 (0.60) CES1TGM2MAOAMAOBPBRM1
SCHEMBL281203 0.75 CES1 (0.60) CES1TGM2BCHEMAOAMAOB
SCHEMBL2838571 0.75 CES1 (0.60) CES1TGM2NSD2BCHEDAO
SCHEMBL734955 0.75 CES1 (1.00) CES1TGM2NSD2BCHEDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747235-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
WO-2025017105-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO disclosed
CN-118420517-A Preparation method of indoline-2, 3-diketone compound 河北医科大学 2024-08-02 CN disclosed
CN-111479806-B D-amino acid oxidase inhibitors and therapeutic uses thereof 心悦生医股份有限公司 2024-01-30 CN disclosed