Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.56 |
| ▸ | SNCA | P37840 | 4/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399794 | 1.00 | ALDH1A1 (0.61) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL10398638 | 0.85 | CASP6 (0.48) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL10398639 | 0.85 | CASP6 (0.48) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL10399731 | 0.79 | MAPT (0.63) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL10819190 | 0.79 | MAPT (0.56) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL10399734 | 0.79 | MAPT (0.63) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL29260672 | 0.78 | MAPT (0.54) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL29260674 | 0.78 | MAPT (0.54) | ALDH1A1NPSR1GAACES2BCHE | |
| Phenyl Isatin SCHEMBL916808 | 0.76 | CES1 (1.00) | ALDH1A1NPSR1GAACES2BCHE | |
| SCHEMBL8296195 | 0.75 | MAPT (0.71) | ALDH1A1NPSR1GAACES2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977178-A | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4861880-A | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0104860-B1 | 1-PHENYL-2(1H,3H)-INDOLONE PSYCHO-THERAPEUTIC AGENTS | PFIZER INC. (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4476307-A | Heteroylidene indolone compounds | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0104860-A1 | 1-Phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1984-04-04 | — | — | EP | disclosed |