Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOS | P01100 | 7/20 | 0.60 |
| ▸ | JUN | P05412 | 7/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.60 |
| ▸ | RELA | Q04206 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15624862 | 0.85 | ALDH1A1 (0.60) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL19320623 | 0.84 | FOS (0.58) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL9496451 | 0.80 | ALDH1A1 (0.51) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL17466945 | 0.78 | FOS (0.53) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL1627061 | 0.78 | FOS (0.53) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL1669574 | 0.78 | RAB9A (0.56) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL30996914 | 0.78 | RAB9A (0.56) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL959574 | 0.76 | CSNK1D (0.54) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL3283452 | 0.75 | ALDH1A1 (0.50) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL6604256 | 0.75 | SMN1; SMN2 (0.63) | NFKB1NFKB2RELAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950648-A | SUBSTITUTED PYRIDO(2,3-D) OR PYRIMIDO(4,5-D) PYRIMIDINE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-08-21 | — | — | US | disclosed |
| EP-0316668-A2 | Use of a tetrahydro-pyrido(2,3-d)pyrimidine for obtaining an analgetic agent | MERCK PATENT GmbH (DE) | 1989-05-24 | — | — | EP | disclosed |