Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.71 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.71 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.71 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.71 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.71 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL10775047 | 0.94 | LMNA (0.62) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL3666042 | 0.93 | LMNA (0.83) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL2103054 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL17541742 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10588660 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10445467 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL6861336 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL1052978 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Alpha-Hexachlorocyclohexane SCHEMBL140813 | 0.84 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL75689 | 0.84 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63289916-A | — | — | None | — | — | JP | disclosed |
| EP-2247737-B1 | FERMENTATION MEDIAS AND PROCESSES THEREOF | BIOCON LTD (IN) | 2018-06-20 | — | — | EP | disclosed |
| US-9255285-B2 | Fermentation medias and processes thereof | BIOCON LIMITED (IN) | 2016-02-09 | — | — | US | disclosed |
| US-8927256-B2 | Fermentation medias and processes thereof | BIOCON LIMITED (IN) | 2015-01-06 | — | — | US | disclosed |
| US-20140141467-A1 | Fermentation Medias and Processes Thereof | BIOCON LIMITED (IN) | 2014-05-22 | — | — | US | disclosed |
| EP-2565272-A2 | Fermentation medias and processes thereof | Biocon Limited (IN) | 2013-03-06 | — | — | EP | disclosed |
| US-7977454-B2 | Transpeptidation, deblocking and conjugation with oligomer which has been solubilized in acetonitrile ; one-pot reaction minimizes production costs | BIOCON LIMITED (IN) | 2011-07-12 | — | — | US | disclosed |
| EP-1907419-B1 | PREPARATION OF INSULIN CONJUGATES | BIOCON LTD (IN) | 2011-01-26 | — | — | EP | disclosed |
| US-20100317056-A1 | FERMENTATION MEDIAS AND PROCESSES THEREOF | BIOCON LIMITED (IN) | 2010-12-16 | — | — | US | disclosed |
| EP-2247737-A2 | FERMENTATION MEDIAS AND PROCESSES THEREOF | Biocon Limited (IN) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009113099-A2 | FERMENTATION MEDIAS AND PROCESSES THEREOF | BIOCON LIMITED (IN) | 2009-09-17 | — | — | WO | disclosed |
| CN-101273705-A | Irrigation installation for plants in dried area | FULAI YAO (CN) | 2008-10-01 | — | — | CN | disclosed |
| EP-1907419-A4 | PREPARATION OF INSULIN CONJUGATES | BIOCON LTD (IN) | 2008-07-23 | — | — | EP | disclosed |
| US-20080139784-A1 | Preparation of Insulin Conjugates | BIOCON LIMITED (IN) | 2008-06-12 | — | — | US | disclosed |
| EP-1907419-A1 | PREPARATION OF INSULIN CONJUGATES | Biocon Limited (IN) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007007345-A1 | PREPARATION OF INSULIN CONJUGATES | BIOCON LIMITED (IN) | 2007-01-18 | — | — | WO | disclosed |
| JP-S63289916-A | MANUFACTURE OF MAGNETIC FILM | YASKAWA ELECTRIC MFG CO LTD | 1988-11-28 | — | — | JP | disclosed |