Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.71 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.71 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.71 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.71 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.71 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL8451614 | 0.93 | LMNA (0.83) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL3666042 | 0.93 | LMNA (0.83) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL6861336 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10588660 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL1052978 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL1040116 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10445467 | 0.86 | LMNA (0.71) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL75689 | 0.84 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL472088 | 0.84 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Alpha-Hexachlorocyclohexane SCHEMBL140813 | 0.84 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158550-B2 | Multilayer catalyst, process for the preparation and use thereof in the partial oxidation of hydrocarbons in gaseous phase | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2012-04-17 | — | — | US | disclosed |
| US-20070100190-A1 | Multilayer catalyst, process for the preparation and use thereof in the partial oxidation of hydrocarbons in gaseous phase | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2007-05-03 | — | — | US | disclosed |
| EP-1631380-A1 | MULTILAYER CATALYST, PROCESS FOR THE PREPARATION AND USE THEREOF IN THE PARTIAL OXIDATION OF HYDROCARBONS IN GASEOUS PHASE | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004105937-A9 | MULTILAYER CATALYST, PROCESS FOR THE PREPARATION AND USE THEREOF IN THE PARTIAL OXIDATION OF HYDROCARBONS IN GASEOUS PHASE | CONSIGLIO NAZIONALE RICERCHE (IT) | 2005-01-20 | — | — | WO | disclosed |
| WO-2004105937-A1 | MULTILAYER CATALYST, PROCESS FOR THE PREPARATION AND USE THEREOF IN THE PARTIAL OXIDATION OF HYDROCARBONS IN GASEOUS PHASE | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2004-12-09 | — | — | WO | disclosed |