Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23699498 | 0.85 | MRGPRX4 (0.41) | MRGPRX4TSHRPOLBALDH1A1CASP1 | |
| SCHEMBL16968396 | 0.84 | KDM4E (0.50) | MRGPRX4ALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8576784 | 0.81 | CA12 (0.46) | MRGPRX4TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11116363 | 0.80 | KDM4E (0.47) | MRGPRX4ALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8572624 | 0.79 | CISD1 (0.66) | ALDH1A1 | |
| SCHEMBL31171383 | 0.78 | CA12 (0.46) | MRGPRX4TSHRPOLBALDH1A1CASP1 | |
| SCHEMBL11255716 | 0.77 | GAA (0.49) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HTT | |
| SCHEMBL8304252 | 0.77 | KEAP1 (0.44) | MRGPRX4TSHRPOLBALDH1A1CASP1 | |
| SCHEMBL8299931 | 0.77 | ALDH1A1 (0.42) | MRGPRX4TSHRALDH1A1CASP1TP53 | |
| SCHEMBL23699456 | 0.77 | TRPV4 (0.43) | MRGPRX4TSHRPOLBALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946858-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-07 | — | — | US | disclosed |
| US-4900739-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORP. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4317929-A | Tetraphenylketazines and isoindolinone pigments obtained therefrom | CIBA-GEIGY CORPORATION (US) | 1982-03-02 | — | — | US | disclosed |
| US-4231931-A | YELLOW TO RED HUES | CIBA-GEIGY CORPORATION (US) | 1980-11-04 | — | — | US | disclosed |