SCHEMBL10403239

SCHEMBL10403239

O=C(O)Cc1nnc(S)s1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.39
HTT P42858 1/20 0.35
HSD17B10 Q99714 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
AKT1 P31749 1/20 0.33
IRS1 P35568 1/20 0.33
GAB1 Q13480 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
APEX1 P27695 1/20 0.31
GLS O94925 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
CYP1A2 P05177 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1809562 0.83 F2 (0.39) F2HTTHSD17B10L3MBTL1SMN1; SMN2
SCHEMBL10769562 0.81 F2 (0.62) F2HTTHSD17B10L3MBTL1SMN1; SMN2
SCHEMBL9662773 0.78 F2 (0.39) F2HTTHSD17B10L3MBTL1AKT1
SCHEMBL10404084 0.76 F2 (0.39) F2HTTHSD17B10SMN1; SMN2NPC1
SCHEMBL9800507 0.76 HSD17B10 (0.64) F2HTTHSD17B10SMN1; SMN2NPC1
SCHEMBL1686855 0.74 F2 (0.70) F2HTTHSD17B10L3MBTL1SMN1; SMN2
SCHEMBL10403237 0.74 F2 (0.39) F2HTTHSD17B10L3MBTL1AKT1
SCHEMBL5545037 0.74 SMN1; SMN2 (0.56) F2HTTHSD17B10L3MBTL1AKT1
SCHEMBL2705929 0.74 GLS (0.45) F2HTTHSD17B10L3MBTL1SMN1; SMN2
SCHEMBL11453155 0.74 SMN1; SMN2 (0.57) HTTHSD17B10SMN1; SMN2RAB9ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4344944-A 7-α-methoxycephalosporin derivatives, and antibacterial drugs onctaining the same EISAI CO., LTD. (JP) 1982-08-17 US claimed
US-7332265-B2 Silver halide color photographic light-sensitive material, and image-forming method FUJIFILM CORPORATION (JP) 2008-02-19 US disclosed
US-7332265-B2 Silver halide color photographic light-sensitive material, and image-forming method FUJIFILM CORPORATION (JP) 2008-02-19 US disclosed
CN-1021910-C LANKACIDIN DERIVATIVES AND PRODUCTION THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1993-08-25 CN disclosed
US-4914206-A ANTIBIOTICS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-04-03 US disclosed
CN-86108176-A Lankacidin derivatives and process for producing the same 1987-10-21 CN disclosed
EP-0226896-A2 Lankacidin derivatives and production thereof Takeda Chemical Industries, Ltd. (JP) 1987-07-01 EP disclosed
EP-0047560-B1 PROCESS FOR THE PREPARATION OF 7-ACYLAMINO-3-(THIO-SUBSTITUTED)METHYL-3-CEPHEM-4-CARBOXYLIC ACID 1-OXIDE DERIVATIVES GIST-BROCADES N.V. (NL) 1985-04-10 EP disclosed
US-4415567-A A 7B-CHROMONE-3-CARBOXAMIDO-2-/4-HYDROXY PHENYL/ACETAMIDO-2-CEPHEM DERIVATIVE EISAI CO., LTD. (JP) 1983-11-15 US disclosed
US-4400509-A WITH HEXAMETHYLDISILANE WITH AN ORGANONITROGEN CATALYST GIST-BROCADES N.V. (NL) 1983-08-23 US disclosed
US-4151352-A CEPHALOSPORINS, BACTERICIDES BRISTOL-MYERS COMPANY (US) 1979-04-24 US disclosed
US-4118566-A Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents BRISTOL-MYERS COMPANY (US) 1978-10-03 US disclosed
US-4112228-A BACTERICIDES BRISTOL-MYERS COMPANY (US) 1978-09-05 US disclosed
US-4103085-A CEPHALOSPORIN ANTIBIOTICS BRISTOL-MYERS COMPANY (US) 1978-07-25 US disclosed
US-4100346-A Certain 7(o-amino-methyl- or methylaminomethylphenyl- or cyclohexadienyl- or thienylacetamide)-3[1-carboxymethyl-(or ethyl- or propyl-)-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids BRISTOL-MYERS COMPANY (US) 1978-07-11 US disclosed
US-4082912-A ANTIBACTERIAL BRISTOL-MYERS COMPANY (US) 1978-04-04 US disclosed
US-4068074-A BACTERICIDES YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) 1978-01-10 US disclosed
US-4068066-A ANTIBIOTICS BRISTOL-MYERS COMPANY (US) 1978-01-10 US disclosed
US-4065622-A O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents BRISTOL-MYERS COMPANY (US) 1977-12-27 US disclosed
US-4013648-A BETA-LACTAM ANTIBIOTICS BRISTOL-MYERS COMPANY (US) 1977-03-22 US disclosed