Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 2/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27940296 | 0.88 | MAPT (0.67) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7010631 | 0.83 | MAPT (0.85) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9941840 | 0.83 | MAPT (0.67) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL109279 | 0.83 | ALDH1A1 (0.67) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL15306501 | 0.80 | KMT2A (1.00) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14740400 | 0.80 | MAPT (0.56) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL628651 | 0.79 | CHRM2 (0.72) | MEN1KMT2AALDH1A1POLB | |
| SCHEMBL1040563 | 0.79 | ALDH1A1 (0.73) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL29003683 | 0.79 | MAPT (0.62) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL647938 | 0.79 | ALDH1A1 (0.70) | MEN1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480941-B1 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | AMBRILIA BIOPHARMA INC (CA) | 2011-01-26 | — | — | EP | disclosed |
| EP-1480941-A2 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | Procyon Biopharma Inc. (CA) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003074467-A2 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | PROCYON BIOPHARMA INC. (CA) | 2003-09-12 | — | — | WO | disclosed |
| US-6528532-B1 | Benzenesulfonamide group | PHARMACOR INC. (CA) | 2003-03-04 | — | — | US | disclosed |