Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.60 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.60 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12443107 | 0.85 | ALDH1A1 (0.81) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL108263 | 0.84 | ALDH1A1 (0.92) | ALDH1A1MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL1042605 | 0.82 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL647939 | 0.82 | RAB9A (0.84) | ALDH1A1MAPTSMN1; SMN2GAAMEN1 | |
| SCHEMBL1040562 | 0.79 | MAPT (0.76) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1041554 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL14900330 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL1042327 | 0.79 | RAB9A (0.78) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL15306501 | 0.79 | KMT2A (1.00) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6940835 | 0.78 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480941-B1 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | AMBRILIA BIOPHARMA INC (CA) | 2011-01-26 | — | — | EP | disclosed |
| EP-1480941-A2 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | Procyon Biopharma Inc. (CA) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003074467-A2 | UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | PROCYON BIOPHARMA INC. (CA) | 2003-09-12 | — | — | WO | disclosed |
| US-6528532-B1 | Benzenesulfonamide group | PHARMACOR INC. (CA) | 2003-03-04 | — | — | US | disclosed |